To evaluate the ingredient, 60 participants with mild to moderately elevated liver enzymes were separated into two groups and tested over the course of 56 days
Karallief, a nutraceutical ingredient company, has published a study on its latest formula, KaraLiv, which indicates the dietary supplement can improve liver function in less than 30 days. Published in the International Journal of Basic & Clinical Pharmacology, the double-blind, parallel, placebo-controlled, randomised clinical trial suggests the ingredient “safely, quickly and effectively supports liver function”.
To evaluate the ingredient, 60 participants with mild to moderately elevated liver enzymes were separated into two groups and tested over the course of 56 days. One group was given a 1,000 mg daily dose of KaraLiv while the other was given a placebo. The study found that the participants taking supplementation outperformed the placebo group.
"We're very excited about these study findings, which clearly demonstrate KaraLiv's safety and efficacy and how this supplement can have a tangible benefit on overall liver support," said Krishna Rajendran, CEO of Karallief. "A healthy liver is essential for a good quality of life, because it maintains healthy blood sugar levels and creates critical nutrients the body needs. And yet there have not been many supplements with herbal ingredients that have gone through such rigorous clinical trials – until now."
At the end of the study, the supplementation group experienced a 40% reduction in Alanine Aminotransferase (ALT) levels in the blood compared to a 19% reduction in the placebo group. ALT levels are crucial because this helps with protein metabolism. When the liver is impaired, ALT can leak into the bloodstream.
The participants taking KaraLiv also saw a 53% reduction in Aspartate Aminotransferase (AST) levels in the blood compared to a 24% reduction in the placebo group. AST is an enzyme found in many organs, including the liver. It’s released into the blood when damage occurs to any of the organs where it is present.
Treatment was associated with 20% reduction in S Alkaline Phosphatase (ALP) levels in the blood compared to a 10% reduction in the placebo group. In the liver, ALP helps in the transport of enzymes and nutrients. ALP levels in the blood increase when there is a blockage or damage to the liver. Subsequent reduction in ALP levels after elevation can indicate that the damage to the liver has reduced or resolved.
KaraLiv is a proprietary ingredient blend of herbal extracts available in powdered form, aimed to provide potency and long-term shelf life. This delivery method also lends flexibility to formulators, so it can be added to supplements, foods and beverages. KaraLiv is a vegan formula made with a 1000 mg per day blend of herbal ingredients designed to support liver health including Momordica charantia, Phyllanthus niruri, Andrographis paniculata, Brassica rapa, Asparagus racemosus, and Zingiber officinale.