A newly published review in the Journal of Exercise and Nutrition sheds light on a powerful combination for athletes and active individuals: Kyowa Hakko USA's Setria Glutathione and citrulline.
The review, titled "Optimizing Nitric Oxide Production for Exercise Performance and Vascular Function: A Narrative Review on the Combination of Glutathione and Citrulline," emphasises how this pairing supports improved nitric oxide production, which is vital for circulation, vascular health and exercise performance.
Often referred to as the body's "master antioxidant," glutathione plays a crucial role by protecting cells, supporting detoxification and maintaining immune function.
But beyond baseline wellness, its role in active nutrition and sports performance is gaining new recognition.
According to this 2025 review, the synergy between glutathione and citrulline has been shown to amplify nitric oxide pathways, with significant benefits for exercise capacity and vascular health.
The review highlights four human clinical trials demonstrating
- improved nitric oxide production and bioavailability
- enhanced blood flow and vascular function
- possible benefits for exercise performance and recovery
- the unique role of Setria Glutathione in optimising these outcomes.
Glutathione has long been recognised as the body's "master antioxidant," essential for overall health by protecting cells, supporting detoxification, and maintaining a strong immune system.
However, according to Katie Emerson, MS, RD, CISSN, its benefits go well beyond basic wellness as it also plays a role in active nutrition and sports performance.
This narrative review highlights four human clinical trials by showcasing the benefits of Setria Glutathione when combined with citrulline.
"This is where science meets innovation and it's a must-read for anyone looking to optimise their health and performance," said Emerson.
The publication further strengthens the growing body of evidence supporting glutathione's role not only in immune and detoxification pathways, but also in advanced sports and vascular nutrition applications.