CETO3® fish oil, which contains high levels of Cetoleic acid, also known as Omega-11, is derived from North Atlantic pelagic fish, harvested and produced in Norway. Immediate processing—from fresh fish to oil in 30 minutes at our production plant—secures a fresh CETO3® oil with high levels of Omega-11. This gives a unique sensory quality with no fishy smell, taste, or reflux.
CETO3® Omega-11, combined with another long-chain omega-9 monounsaturated fatty acid, Gondoic acid, and omega-3 fatty acids EPA and DHA, can be used in liquid applications or in capsules.
CETO3® Omega 11-9-3 has surprising properties which set it apart from conventional fish oils.
Long-chain monounsaturated supplementation, including Omega-11, performs better than olive oil against atherosclerosis.
Atherosclerosis is a chronic disease that affects the arteries, which are the blood vessels that carry oxygen-rich blood from the heart to the body's organs and tissues.
This condition is characterized by the gradual accumulation of deposits of fat, cholesterol, calcium, immune cells, and other substances on the inner lining of the arteries. These deposits form atherosclerotic plaques.
Animal studies have shown that the long-chain monounsaturated fatty acids C20:1 n-9 (Gondoic acid) and C22:1 n-11 (Cetoleic acid) from fish oil suppress the development of atherosclerosis.
It is important to understand that these fatty acids are different from those found in olive oil. The latter does contain omega-9, but with 18 carbons—oleic acid C18:1 n-9. The length of the carbon chain of a fatty acid can change its properties. A study has investigated this.
Mice were fed a Western-style diet alone (control group) or supplemented with 2% long-chain monounsaturated fatty acid (LC-MUFA) or olive oil for 12 weeks.
Omega-11 LC-MUFA, but not olive oil, significantly suppressed the development of atherosclerotic lesions and several levels of inflammatory cytokines in the blood.
Cetoleic acid (Omega-11) effects inflammation related to atherosclerosis
Another study pinpointed Omega-11 (Cetoleic acid)'s preventive effect on atherosclerosis in ApoE -/- mice, genetically exposed to atherosclerosis, fed a Western-style diet with the addition of (A) 3% butter, (B) 3% LC-MUFA C20:1 or (C) 3% Cetoleic acid C22:1n-11. The biomarkers of inflammation supported the evidence of the reduction, beside the reduction of lesions in the aorta by the LC-MUFA and especially Cetoleic acid.
Omega-11 oil performs better on cholesterol reduction than standard fish oil
Omega-3 fish oil supplementation is known to effectively lower plasma triglyceride levels (which are a cardiovascular risk factor), but it is not as effective on cholesterol.
In a preclinical study, rats with type 2 diabetes were fed for 5 weeks either with omega-11-rich herring oil, omega-11-low anchovy oil, or soybean oil for the control group. The content of EPA and DHA was comparable in the two fish oils (herring oil being rich in omega-11). The blood concentration of total cholesterol was 14% lower in the omega-11 group compared to the other two groups.
The omega-11-rich herring oil group had higher fecal excretion of bile acids, but cholesterol production in the liver, hepatic secretion of VLDL, and the liver's ability to absorb cholesterol were similar to those in the control group.
This shows that omega-11 Cetoleic acid lowers cholesterol mainly by facilitating its elimination.
Omega-11 facilitates the conversion of omega-3 precursors into the active form
The omega-3 index corresponds to the sum of the EPA and DHA contents measured in the membranes of red blood cells during a blood test. The omega-3 index is expressed as a percentage of the total red cell fatty acids:
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Below 4%, the omega-3 index is associated with an increased risk of cardiovascular disease.
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Between 4 and 8%, it represents an intermediate status in omega-3.
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Above 8%, it is associated with better cardiovascular health, reduced inflammation, and cognitive benefits.
Another benefit of Cetoleic acid is its action on the metabolism of omega-3s. A pilot, placebo-controlled study showed that supplementation with CETO3® Omega-11-rich oil increases the omega-3 index more than would be expected from the levels of EPA and DHA contained in the oil itself.
In concrete terms, this means that this CETO3® oil provides less omega-3 than conventional fish oil, but that it facilitates the conversion of another omega-3 in the body, alpha-linolenic acid. If you consume plant-based sources of omega-3s such as flax, walnuts, and rapeseed, the alpha-linolenic acid they contain converts very little to EPA. Omega-11 facilitates this conversion, resulting in higher levels of EPA/DHA and an increase in the omega-3 index measured by blood tests.
In summary, the benefits of CETO3® and Omega-11 (Cetoleic acid) include:
1. Reduction of atherosclerosis:
- Long-chain monounsaturated fatty acids like omega-11 suppress the development of atherosclerosis.
- These fatty acids significantly reduce the levels of inflammatory cytokines in the blood.
- Anti-inflammatory index of fatty acids in liver and plasma shows significant increase.
2. LDL and total cholesterol reduction:
- Omega-11 reduces total cholesterol as well as triglycerides in plasma.
- Total cholesterol was 14% lower in the omega-11 group.
- Omega-11 facilitates the elimination of cholesterol by increasing the excretion of bile acids while maintaining normal liver production.
3. Improved omega-3 index:
- Omega-11 promotes the conversion of alpha-linolenic acid (found in plant-based sources of omega-3) to EPA/DHA, bioactive omega-3.
- This action increases the omega-3 index, an indicator of cardiovascular health.
4. Synergistic effect in CETO3® Omega 11-9-3 blends:
- Omega-11 combinations with other fatty acids (such as omega-3 EPA/DHA and long-chain omega-9) provide better cardiovascular performance than conventional fish oils.
These properties highlight the benefits of omega-11 as a promising dietary supplement for cardiovascular and metabolic health. In other words, CETO3® omega-11 fish oil—which is an all-natural mix of omega-11-9-3—provides a real plus for cardiovascular health compared to standard fish oil.
Immediate processing when producing CETO3® Omega-11 fish oil
CETO3® Omega-11 has unique sensory qualities and no reflux due to its immediate processing. Immediately processed fresh fish are turned into oil in as little as 30 minutes, which enables us to make CETO3® with naturally high levels of Omega-11. This enables the use of CETO3® in different applications.
CETO3® is produced by Grøntvedt Biotech, which is part of the Grøntvedt Group, a company that has been working with North Atlantic pelagic fish since 1830.
Sustainability
CETO3® is derived from a Friend of the Sea fishery where the main product is for human consumption. 100% of the fish is utilized in a low carbon footprint operation.
Harvested and produced in Norway.
CETO3® team is exhibiting at Vitafoods in Barcelona @ Stand # 3L256
Sources:
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Yang ZH, Gordon SM, Sviridov D, Wang S, Danner RL, Pryor M, Vaisman B, Shichijo Y, Doisaki N, Remaley AT. Dietary supplementation with long-chain monounsaturated fatty acid isomers decreases atherosclerosis and alters lipoprotein proteomes in LDLr-/- mice. Atherosclerosis. 2017 Jul;262:31-38.
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Yang ZH, Bando M, Sakurai T, Chen Y, Emma-Okon B, Wilhite B, Fukuda D, Vaisman B, Pryor M, Wakabayashi Y, Sampson M, Yu ZX, Sakurai A, Zarzour A, Miyahara H, Takeo J, Sakaue H, Sata M, Remaley AT. Long-chain monounsaturated fatty acid-rich fish oil attenuates the development of atherosclerosis in mouse models. Mol Nutr Food Res. 2016 Oct;60(10):2208-2218.
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Rimmen EV, Mjøs SA, Søfteland E, Gudbrandsen OA. Intake of herring oil, but not of anchovy oil, resulted in a lower serum cholesterol concentration in male Zucker Diabetic Sprague Dawley rats. Br J Nutr. 2024 Sep 14;132(5):547-557.