Bioenergy Life Science (BLS) has been awarded two patents by the US Patent and Trademark Office for its AMPk-regulating, metabolic health and weight management-focused functional ingredient, D-Ribose.
The patents cover the use of D-Ribose as a regulator of AMPk, PGC-1a and citrate synthase levels, as well as the company's method for enhancing AMPk levels in mammals.
AMPk is a highly important precursor in the ATP production process, encouraging the synthesis of ATP when activated.
Notably, reserach has shown that activated AMPk also mitigates inflammation, improves mitochondrial health and encourages fat burning, highlighting the enzyme's potential as a target for metabolic wellness ingredients.
“Several pre-clinical trials have demonstrated orally administered low doses of Bioenergy Ribose, available as RiboActiv, significantly activated AMPk, independent of exercise and without exercise,” says BLS' Director of Scientific Affairs Michael Crabtree.
"RiboActiv is the only patented and scientifically-proven D-Ribose on the market, making it a great tool that allows brands to stand out in the crowded metabolic health, weight management and active nutrition spaces," he adds.
Activating the purine salvage pathway
Although other AMPk-activating nutraceuticals exist on the market, BLS believes that RiboActiv stands out due to its unique ability to act through the purine salvage pathway.
The purine salvage pathway facilitates the reuse of purine bases during DNA synthesis, which reduces the body's reliance on de novo production.
This is particularly important for tissues that have a low de novo capacity, such as the cranial and neural tissue.
"By harnessing the power of the purine salvage pathway, D-Ribose can help optimise mitochondrial function," states Crabtree.
"RiboActiv has also been shown to upregulate PGC-1a, an important molecule for fat loss and energy metabolism regulation," he adds.
According to BLS, the product can also support energy levels, while acting as an antioxidant.
The nutraceutical can be used in a range of formats, including oral strips, mints, time-release tablets, gummies and functional foods.