ATP supplementation enhances anaerobic performance, study finds

Published: 19-Apr-2024

The systematic review and meta-analysis focused on five human clinical studies between 2000 and 2022 and found that ATP supplementation benefitted maximum strength and power in healthy subjects

TSI, a company specialising in the research and development of health-boosting ingredients, have published a systematic review and meta-analysis concluding that oral ATP supplementation helps users safely achieve greater gains in maximal strength compared with a placebo.

The publication was featured in Sports.

“This meta-analysis comes at a time when there is a resurgence of interest in PEAK ATP, as brands throughout the world are increasingly looking to tap into the pre workout market. Numerous studies confirm its immediate benefits for athletes, weekend warriors and everyday exercisers.” Comments Shawn Baier, Vice President of Business Development for TSI’s Innovative Products Division.


A first-of-its kind review and analysis

This is the first systematic review and meta-analysis to analyse the effect of ATP supplementation on anaerobic performance. Variables included maximal strength, maximum repetitions and maximum aerobic power in healthy resistance-trained subjects.

The scientists focused on recent studies from 2000 to 2022. They narrowed their selection to five published human clinical studies, four of which used PEAK ATP. All of the included studies were double-blind, randomised, controlled trials.

In addition to confirming that oral ATP supplementation induced greater maximal strength gains than the placebo, the systematic review and meta-analysis confirmed that daily intakes of 400 mg of ATP for periods up to 12 weeks are safe in healthy subjects.


The four selected PEAK ATP studies were:

  • Wilson, et al 2013: Results of this study showed that PEAK ATP increased strength (147% increase over placebo), increased power (30% increase over placebo), increased lean body mass (100% increase over placebo), and increased muscle thickness (96% increase over placebo).
  • Purpura, et al 2017: This study, involving a repeated sprint exercise test, found that PEAK ATP increased participants’ post-exercise ATP levels, muscle excitability, and sprint performance following a repeated sprint bout.
  • Freitas, et al 2019: The study found a single dose of PEAK ATP improved lower-body resistance training performance and energy expenditure.
  • Dos Santos, et al 2021: This study concluded that a single 400 mg dose of PEAK ATP improved lower body resistance training performance and energy expenditure in recreational resistance-trained participants.

“As more consumers seek non-stimulant energy alternatives for attaining higher peak performance, science clearly affirms they may achieve significant benefits by supplementing with ATP in combination with exercise,” concludes Baier.

PEAK ATP is a clinically validated and patented form of Adenosine 5’-Triphosphate (ATP) Disodium that is identical in structure to ATP produced and used by the human body.

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