In Europe, dementia – a condition marked by the decline of cognitive abilities—currently impacts 10 million people. Alarmingly, this figure is projected to double by 20301. Maintaining a healthy diet, exercising regularly, and keeping the mind active can help delay the onset of dementia. However, many consumers are also exploring various vitamins and supplements that have demonstrated potential in boosting cognitive health, enhancing memory, and improving concentration2.
Mitochondria: the key to anti-ageing
Mitochondria, often referred to as the powerhouse of the cell, plays a critical role in maintaining overall health by converting oxygen and nutrients into energy. However, as we age, mitochondrial function, efficiency, and numbers naturally decline. This deterioration is linked to various age-related health conditions, including sarcopenia, infections, diabetes, and neurodegenerative diseases like dementia.
Fortunately, research has shown that mitochondrial health can be enhanced through two key processes: mitochondrial biogenesis—the creation of new mitochondria—and mitophagy—the removal of damaged mitochondria. These processes help maintain cellular balance and have been associated with delaying the ageing process. A recent study found that mitophagy actively preserves synapses and neuronal function, potentially reducing memory loss and cognitive decline3.
The role of PQQ in mitochondrial biogenesis
As interest in mitochondrial health grows, supplements that support its function are gaining traction. One such compound, Pyrroloquinoline quinone (PQQ), has shown significant promise in activating mitochondrial biogenesis. MGCPQQ, a high-quality, natural form of PQQ developed by Mitsubishi Gas Chemical (MGC), has been extensively studied for its potential to enhance mitochondrial function and support cognitive health.
Research suggests that MGCPQQ interacts with lactate dehydrogenase, triggering the mitochondrial energy production cycle. Additionally, studies indicate that MGCPQQ increases cellular levels of NAD+, a crucial molecule for mitochondrial biogenesis. Other well-known mitochondrial enhancers, such as Resveratrol and NMN (nicotinamide mononucleotide), have demonstrated effectiveness, but test results suggest MGCPQQ is 10 to 1,000 times more potent than these alternatives.
Over the last 40 years, MGC has conducted or supported over 1,000 in vitro, animal, and human clinical studies to assess the safety and efficacy of MGCPQQ. Unlike synthetic alternatives, MGCPQQ is produced through a proprietary fermentation process in Japan, ensuring high purity and adherence to rigorous quality standards.
Protecting memory and cognitive health
Given its impact on mitochondrial function, MGCPQQ has been studied for its potential to support cognitive health. In an animal study, rats fed a PQQ-supplemented diet exhibited enhanced learning and memory compared to the control group. Similar findings were observed in a human clinical trial involving 71 healthy adults aged 45-65. Participants were divided into three groups – one received a PQQ supplement, another received PQQ combined with Coenzyme Q10 (CoQ10), and the third was given a placebo. Over 12 weeks, subjects were evaluated on memory recall, oxidative stress markers, and cognitive function. The results demonstrated that those consuming PQQ-enhanced meals showed notable improvements in word memorization, recall, and Stroop test performance.
A science-backed approach to cognitive longevity
With an extensive research portfolio, MGCPQQ stands out as one of the most rigorously tested supplement ingredients for cognitive and mitochondrial health. Unlike many other compounds, MGCPQQ is officially registered on the European Union’s list of Novel Food Ingredients and is the only ingredient of its kind to be lawfully sold across Europe.
As Europe’s population continues to age, proactive measures to support cognitive function and mitochondrial health become increasingly important. Lifestyle changes, including mental exercises, a healthy diet, and targeted supplementation, can help preserve brain function well into later years. MGCPQQ represents a scientifically validated option for those seeking to maintain cognitive vitality and overall well-being. To learn more about MGCPQQ visit www.mgcpqq.eu.
References
1. http://www.euro.who.int/en/health-topics/noncommunicable-diseases/mental-health/areas-of-work/dementia
2. https://www.who.int/news-room/fact-sheets/detail/dementia
3. https://pubmed.ncbi.nlm.nih.gov/36807425/