Study backs NXT's constipation relief ingredient

Published: 13-Sep-2023

NXT has shared a study published The Journal of Ethnopharmacology that has confirmed Digexin's effects on constipation and moods

NXT USA has announced a new study about its digestive-support ingredient Digexin, that alleviates constipation and boosts moods. 

The Journal of Ethnopharmacology has published the novel ingredient’s new human clinical results, confirming digestive and mood support benefits.

According to the study authors, constipation is a common gastrointestinal (GI) dysfunction that limits social activities and reduces mental and physical well-being. “The present randomised, double-blind, placebo-controlled study evaluated the efficacy and tolerability of a proprietary blend of standardised extracts of Withania somnifera (L.) root and Abelmoschus esculentus (L.) fruit extracts in relieving constipation and improving quality of life in adults,” they said.

After eating a muffin with a special blue dye, study participants noted that transit time was nearly four hours faster in the Digexin group

- Eric Anderson, MD of NXT USA

Benefits validated in human study

“We were confident going into this study as historic use and open-label research showed the natural combination that comprises Digexin afforded users tangible benefits of regularity and mood support,” said Eric Anderson, MD of NXT USA. “The mechanism of the product helps support serotonin production, which works to improve mood while promoting speed of digestion, resulting in people feeling more physically and emotionally comfortable.” 

Physical and emotional benefits

"These findings demonstrate Digexin’s physical and emotional benefits," added Anderson. "We just completed the clinical phase of a second human trial affirming these benefits, and which also showed improvements in the speed of transit. After eating a muffin with a special blue dye, study participants noted that transit time was nearly four hours faster in the Digexin group versus the placebo group."

The researchers concluded: “Our trial demonstrates that Digexin supplementation safely and effectively relieved constipation and improved several associated symptoms, such as gastrointestinal function, bowel clearance, stress, sleep, and quality of life of the study volunteers.” 

Physical assessments and BioMarkers

For the study, 48 male and female participants (age: 25 to 60 years) with functional constipation were randomised into placebo, 300 or 500mg of Digexin groups, and supplemented for 14 consecutive days. 

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Digexin supplementation significantly reduced the Patient Assessment of Constipation-Symptoms (PAC-SYM), Patient Assessment of Constipation-Quality of Life (PAC-QOL), and Gastrointestinal Symptom Rating Scale (GSRS) scores.

Further, supplementation also improved sleep quality and reduced stress, with subjects showing significant improvements in serum serotonin, gastrin, IL-6, IL-10, and cortisol. 

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