On the other hand, many nutrients cannot reveal all their possible benefits because of their low oral bioabsorption.
Over 20 years ago, Indena started working to solve this issue and make botanical extracts and also other natural compounds, actually effective and safe. Thanks to its research and development activity, Indena was able to find and implement the most reliable and customisable solution in the nutraceutical field: Indena Phytosome®, the proprietary multitalented technology platform, a breakthrough 100% food-grade delivery system that optimises the botanical performance, benefits and power of natural and botanical nutrients.
As supported by numerous rigorous scientific studies, Indena Phytosome can:
- optimise bio-absorption of many natural nutrients, especially those from plants
- help to reach the biological target
- help ameliorate product stability
- help minimise variation subject to subject
- optimise interaction with microbiome
- improve the ingredient tolerability.
Indena Phytosome: how it works?
Indena Phytosome is a solid dispersion of botanicals or natural compounds into a 100% food-grade matrix based on lecithin, amphipathic molecules which act as inhibitor of self-aggregation and effective wetting agents.
Indena Phytosome is formulated exclusively with natural dietary ingredients (phospholipids) that act as vectors dynamically reducing the self-aggregation of natural compounds.
In fact, phospholipids and many natural ingredients, such as botanicals, on their own, naturally tend to self-aggregate. In particular, the first aim to join into well-organised structures, while the second aggregate in an inefficient way creating clusters that make the final formulation unstable and rigid. Bi-directional actions are required then, for natural compounds and phospholipids to mutually avoid packing that would reduce absorption by the human body. Phospholipids enclosed in Indena Phytosome formula interact with natural compounds and inhibit their self-aggregation, defeating the primary limit to the full exploitation of their potential. In turn, botanical and natural compounds avoid the self-aggregation of phospholipids.
The result is the achievement of a stable and solid dispersion which allows botanicals and natural ingredients to give their best.
Indena Phytosome is a “functional solid dispersion” of natural or botanical ingredients into lecithin and allows these compounds to efficiently interact with the gut ecosystem in terms of absorption and microbiota interactivity. It thus may significantly optimise bioabsorption without relying on pharmacological adjuvants or structural modification of the ingredients, maintaining tolerability and safety over time.
The Indena Phytosome is a tailor-made composition, to obtain a not well organised, but stable dispersion of phospholipids and our natural ingredient.
What Indena Phytosome is NOT
Indena Phytosome formulations AREN’T:
- chemical derivatives or new chemical entities:
- complexes: no well-defined, three-dimensional association between lecithin and the dispersed nutraceutical exists;
- liposomes, which differ in structure, manufacturing process and stability showing a well-defined micellar or vesicular structure;
- nano formulations
A tailor-made formulation design
Not all the Indena Phytosome are the same.
Each Indena Phytosome formulation is specifically designed to optimise individual characteristics of the final ingredient by modulating several factors, such as: extract-lecithin ratio, particle size, solvent, lecithin origin, process temperature, volume of solvents and addition of food additives.
As for dosage forms, Indena Phytosome formulations are compatible not only with conventional dosage forms like film-coated tablets, hard gelatin capsules and water suspensions (water dispersible powder), but they may also be proponed as smart finished products including chewable tablets, gummies & oral gels,
Science behind
Indena Phytosome is unique, supported by many scientific studies and clinical evidences: it is the science-based original one. It is a very effective delivery system, based on decades of experience and pioneering innovation by Indena and coming from a high-quality industrial scale production.
Over 7 billion servings delivered globally*: this is the most powerful demonstration of Indena Phytosome distinctiveness, efficacy and quality.
*Based on internal sales data of Indena Phytosome nutraceuticals (all SKUs) 2004-2024, taking into consideration the daily intakes recommended by Indena.
For further information, please visit: https://www.indena.com/products/phytosome/?utm_source=partner-dem&utm_medium=email&utm_campaign=phytosome&utm_content=nutraceutical-business-review