Clinical evidence confirms better muscle uptake after supplementation with coenzyme Q10 Phytosome

Published: 14-Dec-2023

A new ex vivo study demonstrates that CoQ10 Phytosome (UBIQSOME) optimises cellular ubiquinone uptake in muscle cells compared with unformulated CoQ10

The confirms the uniqueness of muscle uptake with UBIQSOME supplementation.

Moreover, for the first time in CoQ10 formulations, UBIQSOME resulted in scientific evidence of amelioration of CoQ10 muscle absorption after oral administration. 

Coenzyme Q10 plays a central role in the generation and regulation of cell bioenergy via the mitochondrial oxidative respiratory chain and. hence, ATP production.

CoQ10, however, has a low oral bioavailability owing to its poor water solubility, high molecular weight, low solubility in lipids and low intestinal permeability.

UBIQSOME is the innovative food grade delivery system developed by Indena. Thanks to its Phytosome formulation, UBIQSOME is a food-grade highly bioavailable form, standardised in coenzyme Q10 (18–22% by HPLC), which optimises coenzyme Q10 levels in both the blood and muscles.

The most recent human study on CoQ10 Phytosome involved a crossover design and 8 randomised volunteers who supplemented with 100 mg/daily of CoQ10 for two weeks, delivered both in Phytosome form and in CoQ10 crystalline form.

After supplementation, plasma was collected and low-density lipoproteins (LDL) were extracted, normalised for CoQ10 content and incubated with two different cell lines for 24 h.

The in-vitro results show that UBQ-enriched lipoproteins showed a higher bioavailability compared with crystalline CoQ10-enriched ones in both dermal fibroblasts and myoblasts.

Those data suggest that Phytosome carriers might provide a specific advantage when delivering CoQ10 to skin and muscle tissues.

“We’re happy and proud of these new results from the study led by professor Tiano, which confirm that our UBIQSOME is agreat formulation of coenzyme Q10," says Serena Tongiani, Chief Product Officer at Indena.

"This study demonstrates for the first time in humans that UBIQSOME optimises muscles levels of CoQ10 after oral supplementation compared with baseline." 

Last but not least, UBIQSOME has been recently demonstrated to enhance endothelial function after the first dose in young healthy subjects, showing itself to be an effective support to cardiovascular health and healthy ageing, even in absence of any specific disease."

"All the evidence we've collected in the last few years, including the most recent data, shows that UBIQSOME CoQ10 Phytosome is a reliable and promising ingredient for all traditional applications of CoQ10.”




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