A balanced gut for a longer life: the diversity advantage

Published: 25-Feb-2025

The difference between unhealthy ageing and healthy ageing is in the composition of the microbiome, reports Dr Mahmoud Ghannoum, cofounder and Chief Scientific Officer at Biohm Health

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Healthy ageing is more than just commitment to good habits; the condition of the gut microbiome can make a huge difference in a well-functioning body years down the road.

As humans age, the microbiome evolves.1 In the microbiome of an 8-week-old infant, for example, Actinobacteria reigns and Firmicutes and Bacteroidetes occur in lower amounts.

By contrast, let’s compare the dominant taxa in healthy and frail elderly subjects: in the microbiome of the healthy elderly, Firmicutes overpower Bacteroidetes; but, in the latter, Bacteroidetes tends to dominate. 

Healthy elderly people also have a more diverse and balanced microbiome with more longevity associated bacterial and fungal species (Faecalibacterium and Coprococcus) than their frail counterparts — who tend to have more unhealthy levels of Fusobacterium and Candida albicans

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