Bloomage, a developer and provider of bioactive substances, has released data from a study highlighting the benefits of hyaluronic acid supplementation for better gut health.
The trial, conducted in collaboration with Harvard Medical School, was published in the Gut Microbes journal.
The study
The trial, aimed to test the efficacy and safety of the oral hyaluronic acid solution UltraHA J on female mice, was carried out at the Massachusetts General Hospital.
The mice in this placebo-controlled, randomised study who were in provided with hyaluronic acid received 600 μg per day for the two week trial period.
After the trial period, the severity of gastrointestinal inflammation in mice with induced intestinal damage was measured to compare hyaluronic acid supplementation with no intervention.
The results
Researchers found that supplementation with hyaluronic acid alleviated intestinal inflammation in mice, as well as protecting the gut from baterial colitis by clearing harmful bacteria from the gut microbiome.
They also found that hyaluronic acid could assist the gut’s defence system, as it was able to protect against the infection of C. rodentium.
The presence of A. Muciniphila, which is enriched by hyaluronic acid supplementation, also alleviated C. Rodedntium-related bacterial colitis.
From these results, it can be inferred that hyaluronic acid can positively modulate the gut microbiome, while also promoting the immune response of the gut when exposed to bad bacteria.
“Collectively, these results provide novel insights into the regulatory role of hyaluronan in modulating the gut microbiota and immunity in enteric infection and inflammation, with therapeutic potential for gut microbiome-targeted immunotherapy.” Concluded Tangyou Mao, the lead author of this study.
