Standout market positioning with Quatrefolic

Published: 14-Apr-2026

Bioavailable folate supports collagen production, cell renewal and inside-out skin protection

As awareness grows around the profound impact that stress, poor nutrition and environmental factors can have on skin health, the demand for effective, science-backed solutions that work from the inside out continues to soar. And at the forefront of this nutricosmetics revolution stands a true superstar: Quatrefolic®, the bioavailable form of folate (vitamin B9) that is poised to redefine the very concept of skincare.

Folate, a water-soluble vitamin found naturally in dark green leafy vegetables, nuts and legumes, is a crucial player in DNA replication and the enzymatic reactions that support amino acid synthesis and vitamin metabolism. But as a recent study by the Polytechnic University of Marche has revealed, folate's skin-transforming powers go far beyond these foundational functions.

Particularly in its bioavailable 5-methylhydrofolate (5-MTHF) form, as found in Quatrefolic®, this remarkable nutrient promotes rapid skin cell turnover, helping to keep the complexion healthy and radiant. Folate is also essential for methylation processes that influence how skin cells function, regenerate and respond to environmental stressors. By helping to reduce homocysteine levels and limit oxidative stress, Quatrefolic® acts as an internal defense system against premature aging and UV-induced damage.

But the benefits of Quatrefolic® do not stop there. As a key factor in fibroblast proliferation, it plays a vital role in collagen production, leading to improved skin firmness and a reduction in the appearance of wrinkles. And by increasing the intracellular folate pool, this bioavailable nutrient promotes overall skin health and vitality from the inside out.

Putting it simply, in label-friendly language, Quatrefolic®:

Supports fibroblast proliferation, the main source of collagen production
Encourages skin cell renewal and enhances tissue repair
Delivers inside-out protection, protecting against UV damage by acting as a cell booster.

Recognizing the transformative power of Quatrefolic®, Gnosis by Lesaffre is eager to help formulators and brand owners harness the full potential of this skin-supporting superstar. By embracing the "Think like Nature" mission and making Quatrefolic® the cornerstone of your next nutricosmetic product, you can deliver clinically proven benefits that set their offerings apart in the rapidly growing beauty-from-within market.

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