Research collaboration for Nektium is a success


Zynamite, the patent-pending botanical extract from Nektium, shows an ergogenic effect in women - when administered with either quercetin and tiger nut extract or luteolin - during prolonged sprinting

Nektium R&D team with Professor Jose Calbet and CEO of Nektium Miguel Jimenez

Nektium, an innovative botanical ingredients company that discovers, develops and commercialises science-based ingredients has collaborated with the ULPGC to produce clinical research on its latest ingredient, Zynamite.

The mango leaf extract extract Zynamite, which is a sports nutrition ingredient for the food supplement industry, will fulfil current demand for natural ergogenic and mental energy caffeine replacement products.

Zynamite was researched by Nektium's R&D team over a period of three years. In keeping with Nektium´s evidence-based research philosophy, the product is backed by several preclinical studies and two clinical trials.

The research collaboration between Nektium and the ULPGC was led by Professor José A. L. Calbet, Head of the Human Performance Lab of the Department of Physical Education and member of the Research Institute of Biomedical and Health Sciences (IUIBS). After a promising pilot study, a formal clinical trial was done to investigate the sports performance activities of Zynamite.

The study looked at Zynamite (which is a mango leaf extract) rich in mangiferin administered with either quercetin and tiger nut extract or luteolin. It was found that the combination exerts a remarkable ergogenic effect, increasing muscle power in fatigued subjects and enhancing peak VO2 and brain oxygenation in women during prolonged sprinting. Importantly, the combination of Zynamite, quercetin and tiger nut extract improves skeletal muscle contractile function during ischemia/reperfusion.

The findings were recently published in the journal Frontiers in Physiology in a paper titled “Mangifera indica L. leaf extract in combination with luteolin or Quercetin enhances VO2peak and peak power output and preserves skeletal muscle function during ischemia-reperfusion in humans”. The full scientific paper is available at

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