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Many anti-reflux medications on the market are available in the form of suspensions containing sodium alginate as the active ingredient. Corresponding tablet formulations are still less common, despite their greater convenience and stability.
The study aimed to develop a chewable anti-reflux tablet by direct compression. A formulation composed of VIVAPHARM® Sodium Alginate PH R5, and the excipients PROSOLV® SMCC 50, EMDEX® and PRUV® was developed, leading to an effective solid dosage form to prevent reflux.