NXT USA has announced the results from a new peer-reviewed, randomised, double-blind, placebo-controlled clinical trial published in the Journal of Functional Foods.
Researchers demonstrated that BluNADBooster, a natural NAD+ booster and polyphenol-rich healthy ageing supplement, meaningfully improved key biomarkers of mitochondrial health, energy metabolism, inflammation, cognition, physical performance and quality of life scores.
Additionally, a head-to-head study compared BluNADBooster to the NAD+ precursor benchmark ingredient, nicotinamide riboside (NR), as well as the combination of the two ingredients.
The BluNADBooster ingredient outperformed NR and the blend of both ingredients was the best of all.
The findings support BluNADBooster as a next-generation cellular energy and longevity supplement for adults seeking proactive natural NAD+ support.
"The market has been waiting for an NAD+ solution that goes beyond precursors alone," said Eric Anderson, Managing Director at NXT USA and CEO of Blue Helix Health.
"BluNADBooster represents a next-generation approach — one that strengthens the body’s ability to generate and maintain healthy NAD+ levels while addressing the underlying mechanisms that cause NAD+ to decline with age."
"This study confirms what we’ve believed for years: polyphenols matter and they work in ways synthetic precursors cannot."
Key findings for NAD+, inflammation and longevity
The study evaluated 140 healthy ageing adults who received either a placebo, 500 mg nicotinamide riboside (NR), 1000 mg BluNADBooster alone, or a 500 mg BluNADBooster + 500 mg NR combination.
Results show that BluNADBooster, with its dual mechanism of enhancing NAD+ metabolism and moderating CD38 activity, consistently outperformed placebo across biochemical, physical and cognitive measures.
In the published study, BluNADBooster delivered superior NAD+ support and mitochondrial function, increasing blood NAD+ levels by 26.48% and outperforming NR, which achieved a 22.69% increase.
These gains reflect meaningful improvements in cellular energy and mitochondrial efficiency.
The combination of BluNADBooster with NR produced the largest rise (31.76%) highlighting synergistic effects characteristic of advanced anti-ageing nutraceutical strategies.
The study also demonstrated clinically validated CD38 modulation.
Age-related elevation in CD38 is a major driver of NAD+ depletion and BluNADBooster acted as a natural CD38 inhibitor, reducing enzymatic activity by 17.98%.
This preservation of intracellular NAD+ pools supports healthier energy balance, more efficient metabolic signalling and broader longevity pathways.
Through its rich polyphenol profile, BluNADBooster provided polyphenol-driven inflammation support, lowering key biomarkers associated with systemic inflammation and “inflammaging,” including TNF-α, IL-6 and GDF-15.
By combining synergistic polyphenols from pomegranate and marigold, the formulation functions as a targeted polyphenol supplement that promotes healthier inflammatory balance and reinforces overall cellular resilience.
In addition to metabolic and inflammatory benefits, BluNADBooster delivered notable cognitive support and healthy ageing outcomes.
Participants experienced significant improvements in cognitive performance, as measured by the MMSE-2, reinforcing the supplement’s potential as a cognitive-support nutraceutical for adults seeking better brain function, stress resilience and long-term healthy longevity.
BluNADBooster also contributed to improved physical endurance and energy, with the combination group showing a 9.94% increase in six-minute walk test distance.
Health-related quality of life scores were significantly greater in all groups after 60 days, with the combination therapy of BluNADBooster and NR having the greatest
improvements in energy/fatigue, daily living, bodily pain, emotional well-being, social functioning and general health.
This improvement reflects meaningful gains in mobility, endurance and functional vitality — key outcomes for consumers prioritising active, healthy ageing and overall quality of life.
"This is comprehensive, multidimensional evidence to ensure the formulation truly delivers," said Anderson.
"For the first time, we’re seeing a clinically validated botanical strategy that supports multiple hallmarks of ageing, including mitochondrial efficiency, inflammation and cognitive resilience, within just 60 days."
With its dual-action profile and plant-based formulation, BluNADBooster stands out in the competitive market of NAD+ supplements and longevity-focused formulations.