As consumers demand deeper scientific transparency, the nutraceutical industry faces growing pressure to deliver ingredients backed by high‑quality clinical research. Today’s customers expect more than oversimplified claims. They want rigorous, reproducible scientific evidence relevant to their life stage and health priorities. Moreover, statements such as “clinically studied” are no longer enough so brands must demonstrate the quality of the science behind their ingredients
This is where Veri-te™, a patented biotech-derived-derived source of resveratrol, continues to set itself apart. Backed by one of the most comprehensive scientific portfolios in the resveratrol category, its evidence base has been further strengthened by recent research. New clinical data demonstrate visible improvements in skin aging, in addition to the significant benefits previously reported in postmenopausal women.
A modern understanding of resveratrol: beyond antioxidant properties
Traditional antioxidant narratives no longer resonate with scientifically informed consumers. The perceived low bioavailability of resveratrol fostered a “more is better” mindset, driving demand for high-dose products or technologies focused solely on enhancing absorption. Emerging science is fundamentally reshaping this perspective. For example, the metabolites of resveratrol could be the missing link to explain the French paradox, more so than the actual circulating resveratrol concentrations-dose products or technologies focused solely on enhancing absorption. 1, 2.
A growing body of mechanistic insights now clearly explains its broad health effects, including:
- SIRT1 activation at physiologically relevant low doses
- Improvements in microcirculation and endothelial function, relevant to brain, bone, and skin health
- The contribution of gut-derived metabolites such as lunularin, which may drive additional biological activity
- Modulation of cellular signalling pathways linked to mitochondrial function, metabolic resilience, and inflammatory balance
This evolving science enables brands to move beyond simplistic antioxidant positioning and toward more credible, differentiated mode of action storytelling grounded in modern biological understanding.-of-action storytelling grounded in modern biological understanding.
A new chapter in resveratrol science: visible skin benefits from within
A new randomised, placebo-controlled study involving 140 women aged 40+ provides the first clinical evidence that orally administered resveratrol, as Veri-te™, can significantly improve visible signs of skin aging3.
Participants receiving Veri-te™ capsules demonstrated:
- Significant reductions in wrinkle depth
- Improvements in key features of skin structure and smoothness
- Enhanced overall skin appearance
Dr. Marcia Da Silva Pinto, Category Manager at Lallemand Bio-Ingredients, explains:
“What makes this study important is that we are finally seeing quantifiable, visible improvements from an oral resveratrol supplement. The benefits were not just statistically significant; they were meaningful to the women who participated.”
The RESHAW study: a landmark in women’s health
These new results build upon earlier work, most notably the RESHAW trial (Resveratrol for Healthy Aging in Women), which lasted 2 years, making it the largest and longest human study ever conducted on resveratrol supplementation in postmenopausal women.
Conducted at the University of Newcastle, the clinical trial results generated four peer-reviewed publications4, 5, 6, 7 demonstrating sustained, significant and broad benefits:
- Cognitive health: improved performance in memory and executive function
- Cerebral blood flow: enhanced microcirculation in brain regions linked to cognition
- Bone health: improved bone mineral density and reductions in fracture-related indicators
- Cardiometabolic markers: favourable shifts in vascular function and metabolic parameters
- Quality of life: reduced pain, improved sleep, fewer menopausal symptoms, and better overall well-being
Dr. Da Silva Pinto notes:
“Women are often underrepresented in clinical trials. With RESHAW, the study was designed and powered specifically for women’s physiology, not just adapted as a subgroup analysis. That distinction matters scientifically, and the results speak for themselves.”
The strengths of the science behind Veri-teTM
Scientific credibility has become a core purchase driver. Consumers, especially women aged 35+, are increasingly focused on clinical validation, transparency, and real-world outcomes. Veri-te™ resveratrol is well-positioned to meet these expectations because its clinical program exhibits:
- Robust study designs: adequate sample sizes and long study durations
- Clear primary endpoints: cognitive function, bone integrity, vascular markers, and skin aging
- Diverse, female-focused recruitment: ensuring relevance across key life stages
- Transparency: trials registered on clinicaltrials.gov or conducted under internationally recognised standards
- Independent analysis: peer‑reviewed publications free from sponsor interference
Veri-te™: A key advantage for formulators and evidence-driven brands
For formulators, this means Veri-te™ offers an evidence‑backed story that appeals to both health‑conscious consumers and retailers seeking substantiated innovation, credibility, premium positioning, and relevance across key growth segments. Here is why:
- Clinically demonstrated benefits across multiple life stages
- Visible anti-aging effects through oral supplementation
- A strong and well-defined mechanistic foundation
- Long-term safety and efficacy data
- Clinical research specifically designed and powered for women
References:
- Agbadua OG et al. New Insights into the French Paradox: Free Radical Scavenging by Resveratrol Yields Cardiovascular Protective Metabolites. J Med Chem. 2025 doi: 10.1021/acs.jmedchem.4c03061.
- Campins-Machado FM et al. Microbiota-derived resveratrol metabolites: New biomarkers of red wine consumption are inversely associated with inflammation in a longitudinal study of a Mediterranean population. J Nutr Health Aging. 2025 doi: 10.1016/j.jnha.2025.100542. (2025)
- Rao A, Briskey D, Roche G, Tremblay A, Da Silva Pinto M and Tompkins TA (2025) Trans-resveratrol reduces visible signs of skin ageing in healthy adult females over 40: an 8-week randomized placebo-controlled trial. Front. Aging 6:1727244. doi: 10.3389/fragi.2025.1727244
- Thaung Zaw JJ, Howe PRC, Wong RHX. Sustained Cerebrovascular and Cognitive Benefits of Resveratrol in Postmenopausal Women. Nutrients. 2020 Mar 20;12(3):828. doi: 10.3390/nu12030828.
- Thaung Zaw JJ, Howe PR, Wong RH. Long-term effects of resveratrol on cognition, cerebrovascular function and cardio-metabolic markers in postmenopausal women: A 24-month randomised, double-blind, placebo-controlled, crossover study. Clin Nutr. 2021 Mar;40(3):820-829. doi: 10.1016/j.clnu.2020.08.025.
- Wong RH, Thaung Zaw JJ, Xian CJ, Howe PR. Regular Supplementation With Resveratrol Improves Bone Mineral Density in Postmenopausal Women: A Randomized, Placebo-Controlled Trial. J Bone Miner Res. 2020 Nov;35(11):2121-2131. doi: 10.1002/jbmr.4115.
- Thaung Zaw JJ, Howe PRC, Wong RHX. Long-term resveratrol supplementation improves pain perception, menopausal symptoms, and overall well-being in postmenopausal women: findings from a 24-month randomized, controlled, crossover trial. Menopause. 2020 Aug 31;28(1):40-49. doi: 10.1097/GME.0000000000001643.