Vital Nutrients’ Cortisol Balance study shows plant-based formula supports sleep, mood and stress in the US

Published: 18-Nov-2025

New clinical research finds Cortisol Balance, a plant-based supplement, significantly improves anxiety, stress, sleep and mood in adults

Vital Nutrients has released new research highlighting the potential benefits of Cortisol Balance, a plant-based dietary supplement formulated to support healthy energy, stress response and recovery.

The supplement contains clinically effective levels of ashwagandha, B vitamins, magnesium, boswellia, vegan omega-3, eleuthero extract and copaiba extract.


The study

A randomised, double-blind, placebo-controlled study evaluated Cortisol Balance in 499 healthy adults seeking support for anxiety and stress.

During six weeks, participants received either Cortisol Balance or a placebo.

The supplement was assessed using validated measures of anxiety, stress, sleep and mood.

Findings showed that, in participants who reported moderate levels of anxiousness, Cortisol Balance led to significant improvements in feelings of anxiety, perceived stress, sleep disturbance and mood, compared to placebo.

In this group, up to 85% of respondents reported improvement in both the levels and frequency of anxiousness and stress.


“This study provides important evidence that a comprehensive, systems-based approach to stress management can help people better adapt to the pressures of daily life,” said Dr John P. Troup, Chief Science and Innovation Officer of Blueroot Health, the parent company of Vital Nutrients.

“By supporting cortisol balance and healthy adrenal function, we can help the body manage stress where it starts — not just mask the symptoms — and improve overall well-being without relying on single-ingredient solutions.”

Vital Nutrients’ Cortisol Balance study shows plant-based formula supports sleep, mood and stress in the USUnlike many supplements that draw on isolated ingredient data, Cortisol Balance was evaluated as a finished formula in a large and diverse US population, a notable advancement in supplement research design.

The product’s blend of adaptogenic herbs and nutrients works synergistically to help the body recover, reset and rebalance after stress, supporting the hypothalamic-pituitary-adrenal (HPA) axis, endocannabinoid system and circadian rhythm.

“Especially during the holidays, shifting routines and added pressures can throw off the body’s natural stress response,” said Troup.

“Cortisol Balance helps bring those systems back to equilibrium, supporting calm, focus and quality sleep.”

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