Longvida significant improvement to neuroprotective biomarkers

Researchers at Central Michigan University have taken a closer look at Longvida Optimized Curcumin, and found it outperformed the unformulated curcumin extract in all tested parameters

Curcumin is the primary compound in most standardised turmeric extracts

Previously, the researchers conducted amyloid binding work in vitro with promising results.1

Recently published, in the International Journal of Alzheimer’s Disease, Maiti P et al have compared standard, unformulated curcumin more closely to Longvida with SLCPTechnology.

Longvida outperformed the unformulated 95% curcumin extract in all parameters that were looked at. Longvida showed greater permeability, decreased reactive oxygen species (ROS) production, and prevented apoptic death.2

Gregory Cole, Interim Director at Mary S Easton Alzheimer Center, said: “These new studies from Dr Maiti and Dunbar show that the Longvida formulation retains excellent neuroprotective and amyloid binding activities in vitro.

"The superior bioavailability and sensitivity of Longvida in detecting amyloid deposits in [the] brain are consistent with the promising in vivo human clinical trial retinal amyloid imaging results reported by Neurovision and AIBL trial investigators at international meetings.”

The researchers said: “We also monitored the permeability of SLCP (Longvida) in N2a cells [as 7-day hippocampal neurons] from 0h to 24h and observed that maximum permeability was reached within [the] first hour of SLCP administration and intensity becomes stable up to 24h [after administration].”2

These findings further back the results of the Swinburne study published in 2015.3

Kristen Marshall, Marketing Coordinator at Verdure Sciences, said: “Not only is it very exciting to see these results from Maiti P et al, but it is absolutely fantastic to have additional support for our previous research efforts on Longvida. This new publication brings the full picture into perspective and helps to answer a lot of questions that were previously posed.”

Combined together, these studies show that Longvida’s efficacious free curcumin is delivered in a single daily dose to offer tangible health benefits. The key to the success of Longvida lies within the patented and proprietary Solid Lipid Curcumin Particle Technology, or SLCP. 

References:

1. Maiti P, et al. “A comparative study of dietary curcumin, [Longvida], and other classical amyloid-binding dyes for labelling and imaging of amyloid plaques in brain tissue of 5x-familial mice,” Histochem Cell Biol. 146(5), 609-625 (2016).

2. Maiti P, et al. “Comparative neuroprotective effects of dietary curcumin and Solid Lipid Curcumin Particles [Longvida] in cultured mouse neuroblastoma cells after exposure to Aβ42,” Intl J Alz Dis. 2017, (2017).

3. Cox KH, et al. “Investigation of the effects of Solid Lipid Curcumin [Longvida] on cognition and mood in a healthy older population,” J Psychopharmacol. 29(5), 642-651 (2015).

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