Folate deficiency and polymorphism of the enzymes involved in the folate cycle increases the risk of hyperhomocysteine, a recognised factor of many diseases as cognitive decline and neurological disorders (depression, dementia, Alzheimer), osteoporosis, diabetes, atherosclerosis and vascular diseases.
Homocysteine is a metabolite of the one carbon metabolism, known as the methylation cycle.
Gnosis, which manufacturers and sells active and functional ingredients, aims at protecting human health with three blockbuster products:
Quatrefolic, the glucosamine salt of (6S)-5-methyltetrahydrofolate, is the biologically active form of folate that completely bypasses the "damaged" MTHFR conversion step, overstepping the problem of people with polymorphisms in folate- related enzymes.
Adonat (S-Adenosyl-methionine), the methyl donor for life, plays an important role in the metabolism of homocysteine. A change in the regulation of methylation due to the reduced synthesis of SAMe is among the central mechanisms negatively inducing the effects of hyperhomocysteinemia, which is related to ascular diseases and neurodegenerative disorders. This is because the synthesis in neurotransmitters and proteins - important for the structural integrity of the brain - is disrupted.
As high levels of homocysteine exert disease effects by the increase of oxidative stress damage, Emothion, the effective, in vivo form of Glutathione, helps to restore our body as a greater antioxidant defence by protecting the brain, acting as a free radical scavenger and inhibitor of lipid peroxidation.