Decoding the microbiome: strain-level analysis to separate good from bad

Published: 9-Apr-2025
Digestion

Engaging consumers, clinicians and researchers alike, the gut microbiome has captured widespread attention. Trends such as #GutTok, the rise of “gut shots” and the increasing use of home testing kits reflect a growing interest and understanding of how the microbiome interacts with health (1,2)

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However, this enthusiasm has often outpaced the robust science needed to fully decode and apply micro-biome insights to health research programmes — until now. Dr Jeremy Wilkinson, Microbial Genomics Lead at PacBio, reports.

For years, studies have shown that gut bacteria play a significant role in gastrointestinal diseases, metabolic disorders and even cancer.3

But distinguishing between a healthy microbiome and an unhealthy one remains a challenge because of the limitations of currently available microbiome tests. 

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