Holixer has been shown in human clinical trials, with 170 subjects, to significantly reduce stress and improve subjective sleep quality within 2 weeks.
Participants taking Holixer experienced improved sleep efficiency, fewer nighttime awakenings and more restorative non-REM sleep, leading to better cognitive performance the next day.
“Summer heat spikes stress hormones impacting sleep quality, making it harder to fall and stay asleep,” said Suresh Lakshmikanthan, PhD, Chief Business Officer of Natural Remedies.
“Holixer supports the body’s response to everyday stress and helps maintain healthy cortisol levels, which are critical for sleep regulation.”
In the double-blind, placebo-controlled study published in Frontiers in Nutrition, Holixer users reported a 37% reduction in stress scores, supported by a 66% drop in hair cortisol (a key stress hormone), and showed significant improvement in insomnia symptoms compared with the placebo group within 4 weeks.
Additionally, Holixer helped manage acute stress within 10 minutes and supported healthier blood pressure levels during stress events.
Holixer is one of the first botanical ingredients to be studied for its effects on the cyclic alternating pattern (CAP) cycle — a key indicator of sleep quality.
In the clinical trial currently under peer review, Holixer increased CAP-A1 rates, which are associated with more stable, uninterrupted sleep.
Participants stayed asleep longer without intermittent disturbances, leading to less fragmented sleep.
The study also showed an improvement in sleep latency, meaning participants fell asleep more quickly — a meaningful benefit, especially during hot summer nights when falling asleep can be more difficult.
“With increasing consumer interest in botanical sleep aids that are non-habit forming, and don’t cause next-day drowsiness or grogginess, Holixer offers a clinically evidenced plant-based solution for occasional sleeplessness,” said Lakshmikanthan.
