PycnoCentella: a new research-based combination ingredient for atherosclerosis (part II)

Published: 7-Oct-2025
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Part II of this article explores how PycnoCentella, a novel combination of Pycnogenol and Centellicum, prevents and stabilises atherosclerotic plaques while supporting cardiovascular health with potent antioxidant and anti-inflammatory mechanisms

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In addition to the previously mentioned direct benefits regarding atherosclerosis (see Part I), PycnoCentella also has potent antioxidant properties.

Oxidative stress was observed to be linked to atherosclerotic plaque progression via reactive oxygen species and the generation of oxidised LDL (low-density lipoprotein) cholesterol.16

In several studies, oxidative stress was assessed by measuring free radicals in the plasma before and after PycnoCentella supplementation.

Oxidative stress was reduced by 15% to 21% in the blood of patients with atherosclerosis after 3 months to 4 years of supplementation.5–12  

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