Groupe Berkem unveils two human trials highlighting the significant benefits of Biombalance on gut health

Published: 31-Jul-2025

Groupe Berkem, a leading player in biobased chemistry, announces impressive results for its successful grape seed extract, Biombalance, in its Health, Beauty & Nutrition business area

Part of the BeGrape range, Biombalance is Groupe Berkem’s grape seed extract developed for the nutraceutical market from carefully selected grapes harvested in the Champagne region (France).

Groupe Berkem is a pioneer in polyphenols and the Group’s R&D department constantly invests in research and proprietary preclinical and human trials to get the most out of OPCs, exploring their sought-after benefits on human health.

Groupe Berkem unveils two human trials highlighting the significant benefits of Biombalance on gut health

Recent scientific studies have shown amazing results: rapid and lasting digestive comfort was experienced when Biombalance was taken as a supplement, making it the first and only grape seed extract with proven efficacy in promoting gut health and quality of life.

“With 72% of volunteers stating they didn’t have to change their diet to avoid discomfort any longer, Biombalance supplementation makes a difference to people’s quality of life."

"It’s an important breakthrough for the nutraceutical market,” stated Dr Amandine Brochot, Groupe Berkem Scientific Manager for the Health, Beauty & Nutrition Business area.

Following previous prebiotic results published in Antioxidants, outstanding benefits from two recent human trials are now revealed (human pilot study and human study versus a placebo) demonstrating the following.
 
Proven efficacy after 2 months

  • In a pilot study, more than 9 out of 10 participants agreed that Biombalance was effective in the management of gastrointestinal (GI) discomfort.
  • In human study versus a placebo, nearly 8 out of 10 consumers experienced significant relief from occasional digestive upsets such as gas and abdominal bloating.

Rapid results

  • Noticeable improvements in digestive comfort and quality of life were reported as early as 2 weeks of supplementation, with 500 mg daily intake for 2 months. Three out of four consumers were satisfied with its speed of action after only 4 weeks.

Promotion of digestive comfort

  • 61% of consumers experienced less belly discomfort, including cramps, distension and bloating.
  • 77% of consumers reported improved digestive well-being with a noticeable reduction of digestive discomfort.

Biombalance helps to ease GI discomfort for those who experience it the most: 84% of consumers with more frequent digestive issues reported improvement in their digestive well-being.

Support in Quality of Life
Most users reported improved mood, energy, and daily well-being, with digestive issues having less of an impact on their lifestyle, diet, and relationships.

High satisfaction and recommendation
As a result, more than 80% of consumers (up to 98% in the pilot study) declared being satisfied with Biombalance and convinced of its efficacy, with strong purchase intent (74%) and willingness to recommend to others (77%).

In conclusion, Biombalance stands out in digestive health-promoting ingredients and brings true innovation to brands in the nutraceutical market worldwide.
 
Biombalance is the first and only grape seed extract with proven efficacy on gut health.

  • It is an innovative plant-based ingredient packed with polyphenols that have a prebiotic effect
  • Its results are supported by rigorous proprietary preclinical and human trials revealing five key modes of action with innovative effects on microbiota:
    • prebiotic selective stimulation of good bacteria
    • prebiotic effect: positive impact on Short Chain Fatty Acid production
    • protection against free radicals
    • supporting intestinal wall barrier function
    • supporting a healthy inflammatory response.
  • Rapid and long-lasting digestive comfort during supplementation.
  • The results are trusted by consumers with high satisfaction and recommendation rates.

As highlighted by Nancy Kleperis, Country Manager USA for Groupe Berkem: “The famous French Paradox is no longer proven accurate exclusively for the cardio-vascular sphere. It now resonates also when it comes to grape seeds and gut health.”

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