A randomised, double-blind, placebo-controlled, parallel, multi-centre clinical study has shown that supplementation of 10 mg lutein and 2 mg zeaxanthin-isomers resulted in a statistically significant improvement in central foveal thickness (CFT).
Additionally, a positive correlation was found between CFT and macular pigment optical density (MPOD) levels.
The fovea or fovea centralis is a small depression at the centre of the retina that is responsible for sharp central vision (foveal vision) and highest visual acuity. In simpler terms, foveal vision enables you to perform activities that require visual detailing, like reading, writing, or driving.
The concentration of macular pigments like lutein, zeaxanthin and meso-zeaxanthin peaks at the fovea and is measured through the relationship between CFT and MPOD (macular pigment optical density).
Increased CFT and MPOD levels in the retina may reduce the risk of occupational-induced macular degeneration or age-related macular degeneration (AMD). They protect the retina from irreversible damage caused by blue light, aging, genetic factors, inflammation and oxidation.
Therefore, measuring CFT and its relationship with MPOD is important to determine the physiological status of eye health.
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