Gnosis by Lesaffre was a sponsor for this year's addition of the B Vitamins and Once-Carbon Metabolism Conference.
The event, which was held on the 11–19 August by the Federation of American Societies for Experimental Biology (FASEB) brought together scientists and clinicians to discuss the latest research in vitamin B and one-carbon metabolism.
At the conference, Gnosis' long-term research collaborator Prof. Teodoro Bottiglieri, led a panel at the event during the "Advances in Metabolics" workshop.
This year's meeting brought scientists and clinicians from a range of backgrounds together to present, discuss and evaluate the latest developments in public health and field research.
The event covered a number of topics, including:
- Global deficiencies
- The impact of deficiencies on foetal and post-natal health
- Supplementation
- Vitamin B's role in epigenomics
- The implications of vitamin B in neurological disorders and cognitive health
"Studying metabolomics in relation to B-vitamins and one-carbon metabolism disorders is important because these pathways are crucial for DNA function and overall health,” says Prof. Bottiglieri, Program Director of the Center of Metabolomics at Baylor Scott & White Research Institute in Dallas, TX.
“Understanding metabolic changes can lead to earlier diagnoses, better treatments, and improved outcomes for neurodegeneration
or cardiovascular diseases. In addition, with the advancements made in analytical technology, we are now beginning to better understand the impact of B-vitamin deficiencies on cellular metabolism that results in specific phenotypic expression in individuals that can lead to appropriate therapeutic interventions.”
The potenial of SAMe in infant nutrition products
A recent study by Prof. Bottiglieri discovered that SAMe (S-Adenosylmethionine, the most important methylating agent in the body) is present in much higher concentrations in breast milk compared to other biofluids, highlighting its crucial role in infant development.[1]
This finding could have important implications for breastfeeding and the formulation of infant nutrition products.
“We found that SAMe, crucial for metabolic pathways and neurodevelopment, is present in much higher concentrations in breast milk — likely from breast tissue,” he adds.
“This suggests SAMe plays a vital role in infant growth, but more research is needed to fully understand its significance and potential impact on breastfeeding practices and infant formula compositions.”
Reference
1 Lerin C, Bottiglieri T, et al. “Revisiting One-Carbon Metabolites in Human Breast Milk: Focus on S-Adenosylmethionine.” Nutrients. 2023 Jan; 15(2): 282. Published online 2023 Jan 5. doi: 10.3390/nu15020282