India-based Zeus Hygia Lifesciences has launched its patent-pending BioSOLVE Technology, which is designed to offer higher bioavailability for active ingredients by using food-grade encapsulating excipients.
The goal of BioSOLVE Technology, according to the company, is to encapsulate water-insoluble actives in a food-grade water soluble matrix using novel phase coacervation techniques. This technology reportedly helps to deliver actives in situ at a submicron range with increased water solubility and maximum efficacy.
The carrier used in the encapsulation process is GRAS and used in food applications globally. “So as a major result, Zeus BioSOLVE Technology can be used to make food-grade encapsulation products with various bio-actives to enhance the bioavailability, solubility and stability of the products,” said Shankaranarayanan Jeyakodi, Zeus Hygia co-founder, and Director of Technical Operations.
“The fact that more ingredients are being introduced into the marketplace for novel product development is attractive, yet a fair number of those exhibit poor solubility and bioavailability, and eventually the end user, being consumers, get minimal therapeutic benefits,” said Arunkanth Krishnakumar, Zeus Hygia co-founder and director of business development and strategies. “Our goal was to innovate a platform technology that overcomes these inherent deficiencies to allow them to be used effectively in a wide range of consumer-friendly product delivery forms including but not limited to tablets and capsules.”
“Our novel platform for improving solubility and bioavailability of poorly soluble actives, offers not only a new technology, but one of the most advanced and scalable platform technologies to increase bio-efficacy, potency and bioavailability,” said Krishnakumar.
The hydrophilic carrier system used in Zeus BioSOLVE Technology has emulsifying properties and forms hydrophilic/lipophilic balance around the bioactive molecules, leading to enhanced absorption by the gut wall. The improved bioavailability is due to several factors, the company says, including an increase in water solubility with better dissolution properties, as well as finer and uniform particles with larger surface area.
The technology allows manufacturers to use less of an ingredient for the same deliverable impact, Zeus Hygia says.
“Consumers are quite sophisticated in their knowledge of how supplements work as well as why to take them, and they are equally passionate about obtaining benefits of supplementation in a variety of forms,” said Jeyakodi. “Zeus BioSOLVE Technology offers manufacturers an opportunity to develop truly innovative health-promoting products. In other words, we have removed the formulation limitations.”
