Workshop on oral controlled release
Different types of solid oral dosage forms can be used to accurately control the release of a drug within the gastro intestinal tract. This includes matrix systems and coated dosage forms (eg tablets, pellets and capsules). However, it can be very challenging to provide a desired release profile for a particular drug at a given dose.
Also, the variability of the environmental conditions in the gastro intestinal tract, the potential ethanol-sensitivity of dosage forms containing highly potent drugs, as well as the risk of abuse of controlled release dosage forms containing high amounts of opioids, are important aspects to be considered. This workshop will give an update on the current state of the art of how to best formulate oral controlled release solid dosage forms. An overview on the available excipients, preparation techniques and apparatuses, characterisation methods and future strategies will be given.
The entire spectrum, ranging from engineering aspects during the manufacturing process, the portfolio of commercially available excipients allowing to formulate a large variety of drugs, the underlying mass transport mechanisms and physical principles, characterisation methods for the key properties of the devices as well as potential pitfalls and hurdles to be overcome during product development will be addressed.
Participants will see 6 practical demonstration sessions, allowing them to become familiar with cutting edge equipment and the latest measurement techniques in the field, in particular:
- Tablet coating at an R&D scale (ProCepT)
- Compression (Gamlen Tableting)
- Hot melt extrusion (Thermo Fisher Scientific)
- UV-imaging (Sirius Analytical)
- Dissolution testing (SOTAX)
- Compression coating (Medelpharm)
Event venue: University of Lille, College of Pharmacy
Organiser: APGI
Tel: +33-6-29366739
Web: www.apgi.org
