Quatrefolic® is the glucosamine salt of biological active folate 5-methylfolate (or methyltetrahydrofolate). It is also the bioavailable, active form of folate
Whereas Quatrefolic® doesn’t need any specific metabolism to guarantee all the benefits, the 5-MTHFR provides all the nutritional benefits directly, without “genetic” impacts on the bioavailable blood folate.
The human's body cannot produce folate by itself and necessarily must be introduced by the diet. In vivo, folic acid and food folates must convert by the body to convert dietary supplements to 5-MTHF through a multi-step process where the enzyme MethyleneTetraHydroFolate Reductase (MTHFR) owns a key role.
In some individuals, the activities of the MTHFR enzyme decrease due to their unique genetic patterns and expression: they have polymorphic forms of this enzyme, which are associated with reduced plasma levels of biological active 5-MTHF folate.
Quatrefolic® plays a pivotal role in tissue growth and cell function, and it works with vitamin B12, vitamin B6, and vitamin C to break down and create new proteins.
Cellular regeneration is an ongoing process in the body; our skin layers, nails and hair grow daily, requiring protein and DNA production.
Aimed benefits are tremendous from healthy pregnancy, fertility, well function of the immune system, cardiovascular protection, and balanced homocysteine level in blood.
The World and health Organization has reported that multiple factors influence folate status, including genetics such as the MethyleneTetraHydroFolate Reductase (MTHFR) gene polymorphism. Other factors are the physiological status (e.g. age, pregnancy, lactation) and the limited access to dietary folate sources.
Since the association between MTHFR polymorphism and low folate concentration has been assessed. The direct supplementation of the active form 5-MTHF like Quatrefolic® through prenatal vitamins should strongly be considered as beneficial and advantageous folate.
Quatrefolic® completely bypasses the "damaged" MTHFR conversion step and delivers "finished" folate the body can immediately use without any kind of metabolization and risks to avoid any accumulation of Un Metabolised Folic Acid (UMFA) in the blood, dangerous for health.